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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Homo sapiens (Human)
Gene	CHRM4
Synonym	HM3 M4 receptor cholinergic receptor Chrm-4 cholinergic receptor, muscarinic 4
Disease	Produce mydriasis and cycloplegia for diagnostic purposes Hypertension Irritable bowel syndrome Moderate and severe psychomotor agitation Mydriasis diagnosis Nausea; Vomiting; Emesis Organophosphate poisoning Overactive bladder disorder; Spasm Parkinson's disease Urinary retention Peptic ulcer Peptic ulcer disease; Irritable bowel syndrome; Pancreatitis; Gastritis Solid tumours Peptic ulcer; Gastrointestinal disease Peptic ulcer; Uveitis Glaucoma Gastrointestinal disease Bronchodilator Poison intoxication Chronic obstructive pulmonary disease Cough Central and peripheral nervous diseases Depression Alzheimer disease Dysuria; Urgency; Nocturia; Suprapubic pain Gastric motility disorder; Spasm Acquired nystagmus [ Show all ]
Length	479
Amino acid sequence	MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08173
Protein Data Bank	5dsg
GPCR-HGmod model	P08173
3D structure model	This structure is from PDB ID 5dsg.
BioLiP	BL0339919,BL0339921, BL0339920
Therapeutic Target Database	T20709, T50918
ChEMBL	CHEMBL1821
IUPHAR	16
DrugBank	BE0000405

Ligand

Name	Oxotremorine M
Molecular formula	C11H19N2O+
IUPAC name	trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium
Molecular weight	195.286
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	-0.1
Synonyms	AC1Q6FK0 D02WTM KBio2_005107 N,N,N-trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium OXO-M Trimethyl-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-ammonium; iodide CCG-205035 GTPL303 L000458 NCGC00015758-03 PDSP1_000571 [3H]oxotremorine-M KBio1_000379 LS-176344 NCGC00024979-02 Spectrum_001982 BDBM50005677 D0G4CG KBio2_007675 NCGC00015758-01 trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium CHEBI:38322 GTPL8595 Lopac-O-100 NCGC00015758-04 PDSP2_000569 AC1L1ILG CHEMBL44674 KBio2_002539 N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium NINDS_000379 Tocris-1067 C11H19N2O DivK1c_000379 KBioSS_002548 NCGC00015758-02 oxotremorine-M ZINC1547932 2-Butyn-1-aminium, N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)- 63939-65-1 CHEMBL23957 IDI1_000379 Lopac0_000954 NCGC00024979-01 SCHEMBL4542695 [ Show all ]
Inchi Key	CANZROMYQDHYHR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
PubChem CID	4629
ChEMBL	CHEMBL44674
IUPHAR	303, 8595
BindingDB	50005677
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6309.57 nM	PMID9224827	IUPHAR

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