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GLASS

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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL336303
Molecular formula	C25H23F3N2O4
IUPAC name	6-[6-phenyl-4-[4-[(2,2,2-trifluoroacetyl)amino]phenyl]pyridin-2-yl]oxyhexanoic acid
Molecular weight	472.464
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	5.3
Synonyms	6-{[4-(4-trifluoroacetamidophenyl)-6-phenyl-2-pyridyl]oxy}hexanoic acid 6-{6-Phenyl-4-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-pyridin-2-yloxy}-hexanoic acid BDBM50001638 DATRLPAIFYGEBS-UHFFFAOYSA-N 6-{[4-(4-trifluoroacetamidophenyl)-6-phenyl-2-pyridyl]oxy)hexanoic acid SCHEMBL8987000 6-[[4-[4-(Trifluoroacetylamino)phenyl]-6-phenylpyridin-2-yl]oxy]hexanoic acid [ Show all ]
Inchi Key	DATRLPAIFYGEBS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H23F3N2O4/c26-25(27,28)24(33)29-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)30-22(16-19)34-14-6-2-5-9-23(31)32/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,33)(H,31,32)
PubChem CID	10390056
ChEMBL	CHEMBL336303
IUPHAR	N/A
BindingDB	50001638
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID1333012	BindingDB,ChEMBL
IC50	150.0 nM	PMID1333012	BindingDB,ChEMBL

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