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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Trhr
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	N/A for non-human GPCRs
Length	412
Amino acid sequence	MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
UniProt	Q01717
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4553
IUPHAR	363
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Spectrum3_001780 Bensedin Diazepam-ratiopharm Tensopam Britazepam (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Tranquirit Calmod 5-24-04-00300 (Beilstein Handbook Reference) Valaxona Cercine 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine Valuzepam CS-0653 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one W-5055 Desloneg AAOVKJBEBIDNHE-UHFFFAOYSA-N Zipan Diaquel Amiprol Diazemuls Sedipam Anxicalm Diazepam Desitin Sibazon Atensine Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Reliver Lizan Mentalium Diazetard MLS001424086 Domalium NCGC00260007-01 Duksen Nixtensyn Euphorin P NSC-77518 FT-0632135 Paranten HMS503A15 Plidan Jinpanfan Q-Pam Relanium LA 111 Diazepam [USAN:USP:INN:BAN:JAN] Stesolid Betapam Tox21_202458 C-17931 11100-37-1 Trazepam Caudel 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Valitran 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one Vazen D07JVL 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Wy 3467 Dialag AC1L1EZE Diastat Acudial S.A.R.L. Anlin Diazepam (intranasal, epilepsy) Serenack Apo-diazepam Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Simasedan Baogin La-Iii Ro 5-2807 Mandro Diazepamum Methyldiazepinone Dipaz NC00247 DSSTox_CID_406 Nervium DZP Novazam Faustal Oprea1_126223 Gradual Paxel HY-17027 Pomin KBio3_002780 Quiatril BCP9000199 Diazepam-Eurogenerics T-quil BIDD:PXR0158 Tranqdyn Calmocitene Unisedil CCRIS 6009 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Valium R Condition 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on Vival DEA No. 2765 A3662/0155188 Zepaxid Diapax Aliseum Diazapam SCHEMBL21442 Ansiolisina Diazepam 1.0 mg/ml in Methanol Servizepam Arzepam Diazepam Rectubes Solis Levium MCULE-8990989144 Diazepan leo Metil Gobanal DivK1c_000967 NCGC00178168-03 DTXSID4020406 NINDS_000967 Elcion CR NSC 169897 Freudal Pacitran HMS2051N04 Placidox 2 IDI1_000967 Psychopax Kratium Relaminal Diazepam Stada Spectrum4_000576 Benzopin Diazepamu Tox21_113071 BRN 0754371 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Tranquo-puren Calmpose Valeo Ceregulart 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one Vanconin D-Pam 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Winii Diacepan AB02310 Diastat S.A. R.L AN-23449 Diazemulus Seduksen Anxionil Diazepam Elmu Sibazone Atilen Renborin Lovium Metamidol Dienpax Mono (2-ethylhexyl) phthalate Doval Nellium Dupin Noan Eurosan NSC169897 Gewacalm Parzam Horizon Plumiaz Kabivitrum Q3JTX2Q7TU LA III Diazepam, European Pharmacopoeia (EP) Reference Standard Stesolin Bialzepam Tranimul C06948 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Umbrium CC-26451 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Valium CHEMBL12 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one Vazepam D0Y1YC 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one WY-3467 Dialar AKOS003367969 Diastat, Valium SAM001246536 Ansilive Diazepam (JP17/USP/INN) Serenamin Apozepam Diazepam Intensol Sipam BCP0726000176 Lamra Ro-52807 Mandro-Zep Diazepamum [INN-Latin] Methyldiazepinone (pharmaceutical) Dipezona NCGC00178168-01 DSSTox_GSID_20406 neurolytr il e-Pam Novo-Dipam Faustan Ortopsique GTPL3364 Paxum I06-0194 Pro pam KBioGR_001012 Quievita BDBM50000766 Diazepam-Lipuro Tensium BRD-K16508793-001-01-8 Tranquase Calmociteno 439-14-5 Usempax ap Centrazepam 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Valrelease CPD000058398 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Vivol Desconet A826456 ZINC6427 Diapine Alupram Diazem Sedapam Antenex Diazepam Dak Setonil Assival Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Sonacon Relanium Liberetas Medipam Diazepin MLS000759402 Dizac NCGC00178168-04 Ducene Nivalen Eridan NSC-169897 Frustan Paralium HMS3393N04 Placidox 5 InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Q-pam Kratium 2 Diazepam [USAN:INN:BAN:JAN] Spectrum5_001890 Best [Pharaceutical] Diazepamu [Polish] Tox21_113071_1 BSPBio_003279 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one Tranquo-tablinen CAS-439-14-5 53320-84-6 Valiquid CHEBI:49575 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Vatran D00293 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one WLN: T67 GNV JN IHJ CG G1 KR Diaceplex AC-10561 Diastat (TN) S.a. r.l. An-Ding Seduxen Apaurin Diazepam Fabra Sico Relax Azedipamin Ro 5-2805 LS-122 Methyl diazepinone Dipam Morosan Drenian Nerozen Duxen Notense Evacalm NSC77518 Gihitan Paxate HSDB 3057 Pms-Diazepam KBio1_000967 Quetinil LA-111 BCP23002 Diazepam, United States Pharmacopeia (USP) Reference Standard STK735517 BIDD:GT0105 Trankinon Calmaven 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- UNII-Q3JTX2Q7TU CCG-100997 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Valium (TN) Chuansuan 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Velium DB00829 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. ZB000640 Diapam Alboral Diatran Saromet Ansiolin Diazepam 0.1 mg/ml in Methanol Serenzin Armonil Diazepam Nordic SMR000058398 Lembrol Ruhsitus Mandrozep Diazepan Methyldiazepinone, pharmaceutical Disopam NCGC00178168-02 DSSTox_RID_75566 Neurolytril EINECS 207-122-5 Novodipam Faustan, Paceum Gubex Placidox 10 Iazepam Prozepam Kiatrium Radizepam [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7100.0 nM	PMID2566295	IUPHAR

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