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GPCR

NameType-2 angiotensin II receptor
SpeciesRattus norvegicus (Rat)
GeneAgtr2
Synonymangiotensin II receptor, type 2
MRX88
Agtr2
AT2R
AT2-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length363
Amino acid sequenceMKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProtP35351
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL257
IUPHAR35
DrugBankN/A

Ligand

NameCHEMBL98426
Molecular formulaC32H32Cl3F3N4O4S
IUPAC nameN-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonylcyclobutanecarboxamide;chloroform
Molecular weight732.037
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogPNone
SynonymsN/A
Inchi KeyDAFWMVQKNLIDJK-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H31F3N4O4S.CHCl3/c1-2-3-15-28-35-38(26-13-6-5-12-25(26)31(32,33)34)30(40)37(28)20-21-16-18-22(19-17-21)24-11-4-7-14-27(24)43(41,42)36-29(39)23-9-8-10-23;2-1(3)4/h4-7,11-14,16-19,23H,2-3,8-10,15,20H2,1H3,(H,36,39);1H
PubChem CID44328044
ChEMBLCHEMBL98426
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50100.0 nMPMID8064808ChEMBL

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