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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	MLS000395028
Molecular formula	C24H20N2O5S
IUPAC name	ethyl 2-[[(E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]-4-phenylthiophene-3-carboxylate
Molecular weight	448.493
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.1
Synonyms	2-[[(E)-2-cyano-3-(4-hydroxy-3-methoxy-phenyl)acryloyl]amino]-4-phenyl-thiophene-3-carboxylic acid ethyl ester cid_1527596 SMR000248448 AC1LT7Q6 ethyl 2-[[(E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]-4-phenylthiophene-3-carboxylate ZINC1453716 2-[[(E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)-1-oxoprop-2-enyl]amino]-4-phenyl-3-thiophenecarboxylic acid ethyl ester ethyl 2-[(2E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoylamino]-4-phenyl thiophene-3-carboxylate ST50078726 AKOS001035148 ethyl 2-{[(2E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino}-4-phenylthiophene-3-carboxylate CHEMBL1504949 MolPort-000-455-612 ethyl 2-[[(E)-2-cyano-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enoyl]amino]-4-phenyl-thiophene-3-carboxylate STK949794 BDBM61618 HMS2576O21 [ Show all ]
Inchi Key	CZYYREQPVVSTNX-GZTJUZNOSA-N
Inchi ID	InChI=1S/C24H20N2O5S/c1-3-31-24(29)21-18(16-7-5-4-6-8-16)14-32-23(21)26-22(28)17(13-25)11-15-9-10-19(27)20(12-15)30-2/h4-12,14,27H,3H2,1-2H3,(H,26,28)/b17-11+
PubChem CID	1527596
ChEMBL	CHEMBL1504949
IUPHAR	N/A
BindingDB	61618
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2753.09 nM	N/A	BindingDB
IC50	2753.09 nM	PubChem BioAssay data set	ChEMBL

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