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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Mus musculus (Mouse)
Gene	Htr2b
Synonym	5-HT-2B serotonin receptor 2B NP75 protein 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F stomach fundus serotonin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
UniProt	Q02152
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2583
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3936595
Molecular formula	C20H23N3O3
IUPAC name	1-(2,3-dihydroindol-1-yl)-2-[(2S)-2-(pyridin-3-yloxymethyl)morpholin-4-yl]ethanone
Molecular weight	353.422
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	1.7
Synonyms	BDBM186930 SCHEMBL14062013 US9079895, 20s US9079895, 21s
Inchi Key	XYHRHHHLNLGIRG-SFHVURJKSA-N
Inchi ID	InChI=1S/C20H23N3O3/c24-20(23-9-7-16-4-1-2-6-19(16)23)14-22-10-11-25-18(13-22)15-26-17-5-3-8-21-12-17/h1-6,8,12,18H,7,9-11,13-15H2/t18-/m0/s1
PubChem CID	71062889
ChEMBL	CHEMBL3936595
IUPHAR	N/A
BindingDB	186930
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7641.0 nM	, None	BindingDB,ChEMBL
Ki	8808.0 nM	None	ChEMBL

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