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GPCR

NameFree fatty acid receptor 2
SpeciesMus musculus (Mouse)
GeneFfar2
SynonymFFA2 receptor
FFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length330
Amino acid sequenceMTPDWHSSLILTAYILIFLTGLPANLLALRAFMGRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISMERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQEQLDVVLPVRLELCLVLFFVPMAVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFYLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLIRNPASSMLGRGAKETVEGTKMDRGGSQAEGVQSSEFVTE
UniProtQ8VCK6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3309047
IUPHARN/A
DrugBankN/A

Ligand

Name(S)-4-CMTB
Molecular formulaC14H14ClFN2OS
IUPAC name(2S)-2-(4-chlorophenyl)-N-(5-fluoro-1,3-thiazol-2-yl)-3-methylbutanamide
Molecular weight312.787
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.5
Synonyms(2S)-2-(4-chlorophenyl)-N-(5-fluoro-1,3-thiazol-2-yl)-3-methylbutanamide
D05UBB
(S)-2-(4-chlorophenyl)-N-(5-fluorothiazol-2-yl)-3-methylbutanamide
GTPL3420
CHEMBL594525
[ Show all ]
Inchi KeyVMELOMANPNYLFR-LBPRGKRZSA-N
Inchi IDInChI=1S/C14H14ClFN2OS/c1-8(2)12(9-3-5-10(15)6-4-9)13(19)18-14-17-7-11(16)20-14/h3-8,12H,1-2H3,(H,17,18,19)/t12-/m0/s1
PubChem CID46226252
ChEMBLCHEMBL594525
IUPHAR3420
BindingDB50305980
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.7 uMPMID20005104ChEMBL

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