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GPCR

NameMuscarinic acetylcholine receptor M5
SpeciesHomo sapiens (Human)
GeneCHRM5
SynonymM5R
M5 receptor
cholinergic receptor
cholinergic receptor, muscarinic 5
DiseaseUrinary incontinence
Colitis
Dysmenorrhea
Irritable bowel syndrome
Myasthenia gravis
[ Show all ]
Length532
Amino acid sequenceMEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProtP08912
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT79961
ChEMBLCHEMBL2035
IUPHAR17
DrugBankBE0000247, BE0004890

Ligand

NameVU0467154
Molecular formulaC17H15F3N4O3S2
IUPAC name5-amino-3,4-dimethyl-N-[[4-(trifluoromethylsulfonyl)phenyl]methyl]thieno[2,3-c]pyridazine-6-carboxamide
Molecular weight444.447
Hydrogen bond acceptor10
Hydrogen bond donor2
XlogP3.4
Synonyms1451993-15-9
HY-112209
BDBM50207517
VU-0467154
CS-0044134
[ Show all ]
Inchi KeyUDSFKIFLJPECRN-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H15F3N4O3S2/c1-8-9(2)23-24-16-12(8)13(21)14(28-16)15(25)22-7-10-3-5-11(6-4-10)29(26,27)17(18,19)20/h3-6H,7,21H2,1-2H3,(H,22,25)
PubChem CID73774630
ChEMBLCHEMBL3915634
IUPHARN/A
BindingDB50207517
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<30000.0 nMPMID27939174BindingDB,ChEMBL

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