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GPCR

Name	Alpha-2C adrenergic receptor
Species	Mus musculus (Mouse)
Gene	Adra2c
Synonym	alpha2C-adrenoceptor alpha2-C4 Alpha-2CAR Alpha-2C adrenoreceptor Alpha-2C adrenoceptor alpha-2C adrenergic receptor alpha-2 adrenergic receptor subtype C4 adrenergic receptor Adrenergic alpha2C- receptor class I ADRA2RL2 ADRA2L2 Adra-2c [ Show all ]
Disease	N/A for non-human GPCRs
Length	458
Amino acid sequence	MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWVPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	Q01337
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4826
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	norepinephrine
Molecular formula	C8H11NO3
IUPAC name	4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight	169.18
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-1.2
Synonyms	4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol Norepinephrine [INN:JAN] FT-0679201 4786-EP2287165A2 Pharmakon1600-01500436 I01-15661 4786-EP2308864A1 SMR000058585 KBioSS_001489 STK503776 Levarterenol Adrenaline Impurity X4W3ENH1CV (+)-Norepinephrine Levonoradrenaline ANW-74377 (-)-Norepinephrine NCGC00159406-04 BSPBio_002079 (R)-Norepinephrine NCGC00255328-01 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- Noradrenalina D07MOX 21779-EP2292620A2 Noreinefrina [INN-Spanish] DSSTox_GSID_23378 Ecteinascidins 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol Norepirenamine HMS2089E18 4786-EP2298776A1 SBI-0050082.P003 KBio2_001489 4786-EP2311831A1 Spectrum2_001064 L-3,4-dihydroxyphenylethanolamine 66197-73-7 to_000024 AKOS006345192 (-)-Arterenol LS-42676 BDBM50029051 (R)-(-)-Norepinephrine NCGC00159406-07 C00547 1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)- Nor adrenalin (TN) CTK4C1344 21779-EP2269990A1 Noradrenaline (JP15) 21779-EP2305669A1 21779-EP2314571A2 Norepinephrine Noradrenalin FT-0603221 4786-EP2284171A1 PDSP1_001111 HSDB 7772 4786-EP2305677A1 SFLSHLFXELFNJZ-QMMMGPOBSA-N KBio3_001579 4899-05-2 Spectrum5_001068 L-Noradrenaline AB00052424_08 UNII-X4W3ENH1CV Levoarterenol ALBB-006229 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2 MLS006010883 bmse000404 (R)-4-(2-Amino-1-hydroxyethyl)catechol NCGC00159406-10 CCG-40104 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)- Noradrenalin d-Norepinephrine 21779-EP2287165A2 Norartrinal DivK1c_000230 4-[(1R)-2-amino-1-hydroxy-ethyl]benzene-1,2-diol norepinephrinum GTPL505 4786-EP2287166A2 PubChem6074 IDI1_000230 4786-EP2308873A1 SPBio_001048 l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol 51-40-1 (l-tartrate (1:1)) Sympathin E Levarterenolo Adrenor xi-Norepinephrine (-)-(R)-Norepinephrine Levonorepinephrine API0003193 (-)-Norepinephrine, >=98%, crystalline NCGC00159406-05 C-05156 025N592 NINDS_000230 CHEMBL1437 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)- Noradrenalina [Italian] D0R2UN 21779-EP2298731A1 norepinefrina DSSTox_RID_77004 Norepinephrine (INN) EINECS 200-096-6 4786-EP2270011A1 NSC-757246 HMS2091J08 4786-EP2305644A1 SC-04955 KBio2_004057 4786-EP2314571A2 Spectrum3_000520 L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol AB00052424-06 TR-005105 AKOS015854572 (-)-Arterenol free base LT03330026 Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (+)- (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol NCGC00159406-08 CAS-51-41-2 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- Nor-adrenaline D-(-)-Noradrenaline 21779-EP2272847A1 Noradrenaline (JP17) DB00368 21779-EP2311828A1 21779-EP2377510A1 Norepinephrine [INN:BAN:JAN] FT-0658803 4786-EP2287163A1 PDSP2_001095 HY-13715 4786-EP2305678A1 SGCUT00123 KBioGR_000635 Spectrum_001009 L-Norepinephrine AC1L96ZT W-105896 (+)-Noradrenaline Levonor AN-24392 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2-?amino-?1-?hydroxyethyl]?- NCGC00159406-03 BRN 4231961 (R)-Noradrenaline NCGC00159406-11 CHEBI:18357 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI) Noradrenalin, l- D00076 21779-EP2287166A2 Noreinefrina DSSTox_CID_3378 DTXSID5023378 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol Norepinephrinum [INN-Latin] HMS1920B08 4786-EP2292620A2 R-norepinephrine KBio1_000230 4786-EP2308875A1 SPECTRUM1500436 l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol 51-41-2 Tox21_301944 AJ-09755 ZINC57624 (-)-alpha-(Aminomethyl)protocatechuyl alcohol Levophed Arterenol (R)-( C)-Norepinephrine NCGC00159406-06 C-4015 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)- Nor adrenalin CS-0007744 138-65-8 noradrenaline D53D5E3A-2360-4CA9-8031-6C2CD4062FD5 21779-EP2298742A1 NOREPINEPHIRINE Norepinephrine l-Tartrate (1:1) FCH920095 4786-EP2280010A2 NSC757246 HMS500L12 4786-EP2305648A1 SCHEMBL2609 KBio2_006625 4786-EP2316836A1 Spectrum4_000078 L-arterenol AB00052424_07 UNII-K294OAI79V component SFLSHLFXELFNJZ-QMMMGPOBSA-N Levarterenolo [DCIT] Aktamin (-)-NORADRENALINE MFCD00025592 Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol NCGC00159406-09 CC-33071 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI) Nor-Epirenan d-Arterenol 21779-EP2284170A1 Noradrenalinum DermX 21779-EP2311835A1 [ Show all ]
Inchi Key	SFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi ID	InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID	439260
ChEMBL	CHEMBL1437
IUPHAR	505
BindingDB	50029051
DrugBank	DB00368
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	650.0 nM	None	ChEMBL

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