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GPCR

Name	Alpha-1D adrenergic receptor
Species	Mus musculus (Mouse)
Gene	Adra1d
Synonym	alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor Adra-1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R ADRA1A ADRA1 Gpcr8 [ Show all ]
Disease	N/A for non-human GPCRs
Length	562
Amino acid sequence	MTFRDILSVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPGATGGSAVVGTGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWPSLRPPLASLDRRPALRLCPQPAHRTPRGSPSPHCTPRPGLRRHAGGAGFGLRPSKASLRLREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDLSNLRETDI
UniProt	P97714
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2130
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3986651
Molecular formula	C22H28N2O3
IUPAC name	(2S)-4-[2-(2,3-dihydroindol-1-yl)ethyl]-2-[(3-methoxyphenoxy)methyl]morpholine
Molecular weight	368.477
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.4
Synonyms	US9079895, 25s BDBM186937 ROKNCKQMECSPFV-NRFANRHFSA-N (S)-4-(2-(Indolin-1-yl)ethyl)-2-((3-methoxyphenoxy)methyl)morpholine SCHEMBL14061752
Inchi Key	ROKNCKQMECSPFV-NRFANRHFSA-N
Inchi ID	InChI=1S/C22H28N2O3/c1-25-19-6-4-7-20(15-19)27-17-21-16-23(13-14-26-21)11-12-24-10-9-18-5-2-3-8-22(18)24/h2-8,15,21H,9-14,16-17H2,1H3/t21-/m0/s1
PubChem CID	71062708
ChEMBL	CHEMBL3986651
IUPHAR	N/A
BindingDB	186937
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6448.0 nM	, None	BindingDB,ChEMBL

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