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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Mus musculus (Mouse)
Gene	Htr2b
Synonym	5-HT-2B serotonin receptor 2B NP75 protein 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F stomach fundus serotonin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
UniProt	Q02152
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2583
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3979116
Molecular formula	C21H24N2O3
IUPAC name	1-(2,3-dihydroindol-1-yl)-2-[(2S)-2-(phenoxymethyl)morpholin-4-yl]ethanone
Molecular weight	352.434
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.7
Synonyms	BDBM186926 QTIAESZAMKLZSK-IBGZPJMESA-N (S)-1-(Indolin-1-yl)-2-(2-(phenoxymethyl)morpholino)ethanone SCHEMBL14061558 US9079895, 18s
Inchi Key	QTIAESZAMKLZSK-IBGZPJMESA-N
Inchi ID	InChI=1S/C21H24N2O3/c24-21(23-11-10-17-6-4-5-9-20(17)23)15-22-12-13-25-19(14-22)16-26-18-7-2-1-3-8-18/h1-9,19H,10-16H2/t19-/m0/s1
PubChem CID	71062560
ChEMBL	CHEMBL3979116
IUPHAR	N/A
BindingDB	186926
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6416.0 nM	, None	BindingDB,ChEMBL

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