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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Homo sapiens (Human)
Gene	LPAR1
Synonym	lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9070858} LPA-1 LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	Idiopathic pulmonary fibrosis
Length	364
Amino acid sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	Q92633
Protein Data Bank	4z36, 4z35, 4z34
GPCR-HGmod model	Q92633
3D structure model	This structure is from PDB ID 4z36.
BioLiP	BL0315557, BL0315553, BL0315554, BL0315555, BL0315556, BL0315558
Therapeutic Target Database	T92640
ChEMBL	CHEMBL3819
IUPHAR	272
DrugBank	N/A

Ligand

Name	CHEMBL3966386
Molecular formula	C26H24FNO4
IUPAC name	4-[[cyclopropylmethyl-[4-(2-fluoro-6-methylphenoxy)benzoyl]amino]methyl]benzoic acid
Molecular weight	433.479
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.1
Synonyms	SCHEMBL16506982 US9464060, 40 BDBM251704
Inchi Key	ONHLWLKFAFELOK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H24FNO4/c1-17-3-2-4-23(27)24(17)32-22-13-11-20(12-14-22)25(29)28(15-18-5-6-18)16-19-7-9-21(10-8-19)26(30)31/h2-4,7-14,18H,5-6,15-16H2,1H3,(H,30,31)
PubChem CID	117903316
ChEMBL	CHEMBL3966386
IUPHAR	N/A
BindingDB	251704
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	160.0 nM	, None	BindingDB,ChEMBL

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