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GPCR

Name	Free fatty acid receptor 3
Species	Rattus norvegicus (Rat)
Gene	Ffar3
Synonym	FFA3 receptor FFA3R G protein-coupled receptor 41 G-protein coupled receptor 41 GPCR41 GPR41 LSSIG [ Show all ]
Disease	N/A for non-human GPCRs
Length	319
Amino acid sequence	MDTSFFPGNHWLFFSVDLLVFLVGLPLNVMALVVFVNKLRRRPVAVDLLLLNLTISDLLLLLFLPFRIVEAACGMKWILPFIFCPLSGFLFFTTIYLTSLFLMTVSIERFLSVAYPLWYKTRPRLAQAGLVSGICWFLASAHCSVIYVTEYWGNATYSQGTNGTCYLEFREDQLAILLPVRLEMAVVLFMVPLCITSYCYSRLVWILSQGASRRRRKRVMGLLVATLLIFFVCFGPYNMSHVVGYVRGESPTWRSYVLLLSTLNSCIDPLVFYFSSSKFQADFHQLLSRLIRACVPWTQEVSLELKVKNGEEPSKECPS
UniProt	B2GV46
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3886125
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Pivalic acid
Molecular formula	C5H10O2
IUPAC name	2,2-dimethylpropanoic acid
Molecular weight	102.133
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	1.5
Synonyms	16419-EP2316459A1 NCGC00257979-01 2,2-Dimethylpropionic acid; Trimethylacetic acid 6745-EP2298763A1 pivaloic acid 6745-EP2374790A1 S04-0120 acide 2,2-dimethylpropanoique Tox21_200425 AN-23884 Versatic 5 CHEMBL322719 DTXSID8026432 IUGYQRQAERSCNH-UHFFFAOYSA-N Kyselina pivalova [Czech] M-6153 2,2,2-trimethylacetic acid NSC 65449 6745-EP2275401A1 Pivalic acid, 99% 6745-EP2298779A1 Propionic acid, 2,2-dimethyl- AB1002486 ST2413688 ACMC-209p14 trimethyl-acetic acid BP-30032 ZINC7993 Dimethylpropionic acid EINECS 200-922-5 KS-00000145 16419-EP2275401A1 16419-EP2305646A1 MolPort-001-779-774 2,2-DIMETHYLPROPANOIC ACID P0461 6745-EP2292590A2 Pivalinsaeure 6745-EP2311816A1 RP18767 AC1Q5RPB tert-C4H9COOH AKOS000119013 Trimethylacetic acid; 2,2-Dimethylpropanoic acid; Neopentanoic acid CHEBI:45133 DSSTox_GSID_26432 HSDB 5211 Kyselina 2,2-dimethylpropionova [Czech] 2,2 dimethylpropanoic acid Neopentanoic acid 4-02-00-00908 (Beilstein Handbook Reference) Pivalic acid (ACD/Name 4.0) 6745-EP2298767A1 PivOH 75-98-9 SC-16199 acide pivalique TRA0076585 ANW-36710 WLN: QVX1&1&1 CS-D1464 EBD16617 J-523981 .alpha.,.alpha.-Dimethylpropionic acid LMFA01020073 MCULE-7166067227 2,2-dimethyl-propanoic acid NSC-65449 6745-EP2277861A1 Pivalic acid; 6745-EP2308839A1 PubChem16826 AC1L1MHI STL264139 AI3-04165 Trimethylacetic acid BRN 0969480 Dimethylpropionic acid (Related) F2191-0097 KSC377A9F 16419-EP2281563A1 16419-EP2311842A2 NCGC00248606-01 2,2-Dimethylpropionic acid PIV 6745-EP2292597A1 Pivalinsaure 6745-EP2311817A1 RTX-012537 Acetic acid, trimethyl- tert-Pentanoic acid alpha,alpha-Dimethylpropionic acid UNII-813RE8BX41 DSSTox_RID_78111 InChI=1/C5H10O2/c1-5(2,3)4(6)7/h1-3H3,(H,6,7 Kyselina pivalova LS-117395 2,2,-dimethylpropionic acid Neovaleric acid 6745-EP1441224A2 Pivalic acid solution, 1 M in dichloromethane 6745-EP2298772A1 Propanoic acid, 2,2-dimethyl- 813RE8BX41 SCHEMBL3613 acido pivalico trimethyl acetic acid BC207643 Z1258943356 CTK2H7092 EC 200-922-5 KB-259328 1184-88-9 (hydrochloride salt) MFCD00004194 2,2-dimethyl-propionic acid NSC65449 6745-EP2289883A1 pivalicacid 6745-EP2308858A1 Pvalc acd AC1Q1LRO tert-Butyl carboxylic acid AJ-08308 Trimethylacetic acid, 99% CAS-75-98-9 DSSTox_CID_6432 FT-0656670 Kyselina 2,2-dimethylpropionova 16419-EP2289890A1 [ Show all ]
Inchi Key	IUGYQRQAERSCNH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C5H10O2/c1-5(2,3)4(6)7/h1-3H3,(H,6,7)
PubChem CID	6417
ChEMBL	CHEMBL322719
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	500000.0 nM	None	ChEMBL

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