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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	Q9QYN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4124
IUPHAR	264
DrugBank	N/A

Ligand

Name	CHEMBL459542
Molecular formula	C28H40N2
IUPAC name	4-methyl-1-[2-[4-[4-[2-(4-methylpiperidin-1-yl)ethyl]phenyl]phenyl]ethyl]piperidine
Molecular weight	404.642
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	6.7
Synonyms	BDBM50412476
Inchi Key	CYSDCSLGWAVYPG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H40N2/c1-23-11-17-29(18-12-23)21-15-25-3-7-27(8-4-25)28-9-5-26(6-10-28)16-22-30-19-13-24(2)14-20-30/h3-10,23-24H,11-22H2,1-2H3
PubChem CID	44588278
ChEMBL	CHEMBL459542
IUPHAR	N/A
BindingDB	50412476
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	54.95 nM	PMID18976927	BindingDB,ChEMBL

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