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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279666
Molecular formula	C19H19N5O4
IUPAC name	3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-5-[(4-hydroxyphenyl)methyl]imidazolidine-2,4-dione
Molecular weight	381.392
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.5
Synonyms	CHEMBL3926716 BDBM211311 US9247759, 10-59
Inchi Key	HUOZOTXZVRHQFH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H19N5O4/c1-11-16(12(2)28-22-11)10-23-9-14(8-20-23)24-18(26)17(21-19(24)27)7-13-3-5-15(25)6-4-13/h3-6,8-9,17,25H,7,10H2,1-2H3,(H,21,27)
PubChem CID	57422474
ChEMBL	CHEMBL3926716
IUPHAR	N/A
BindingDB	211311
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	330.0 nM	None	ChEMBL
IC50	330.0 nM	N/A	BindingDB

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