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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Homo sapiens (Human)
Gene	LPAR1
Synonym	lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9070858} LPA-1 LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	Idiopathic pulmonary fibrosis
Length	364
Amino acid sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	Q92633
Protein Data Bank	4z36, 4z35, 4z34
GPCR-HGmod model	Q92633
3D structure model	This structure is from PDB ID 4z36.
BioLiP	BL0315557, BL0315553, BL0315554, BL0315555, BL0315556, BL0315558
Therapeutic Target Database	T92640
ChEMBL	CHEMBL3819
IUPHAR	272
DrugBank	N/A

Ligand

Name	CHEMBL3915800
Molecular formula	C31H29NO4
IUPAC name	2-[4-[[(3-methoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]benzoic acid
Molecular weight	479.576
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	6.3
Synonyms	BDBM50195581 SCHEMBL706511
Inchi Key	GSYGAEACTSMQPG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H29NO4/c1-36-27-13-7-12-26(21-27)30(33)32(20-8-11-23-9-3-2-4-10-23)22-24-16-18-25(19-17-24)28-14-5-6-15-29(28)31(34)35/h2-7,9-10,12-19,21H,8,11,20,22H2,1H3,(H,34,35)
PubChem CID	66774300
ChEMBL	CHEMBL3915800
IUPHAR	N/A
BindingDB	50195581
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1300.0 nM	PMID27774128	BindingDB,ChEMBL

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