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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279209
Molecular formula	C20H21N5O3
IUPAC name	1-benzyl-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-5-methylimidazolidine-2,4-dione
Molecular weight	379.42
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	1.9
Synonyms	CHEMBL3979194 US9247759, 10-43 BDBM211295 DTORSKIHKJYASR-UHFFFAOYSA-N 1-benzyl-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5-methylimidazolidine-2,4-dione
Inchi Key	DTORSKIHKJYASR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21N5O3/c1-13-18(15(3)28-22-13)12-23-11-17(9-21-23)25-19(26)14(2)24(20(25)27)10-16-7-5-4-6-8-16/h4-9,11,14H,10,12H2,1-3H3
PubChem CID	57944930
ChEMBL	CHEMBL3979194
IUPHAR	N/A
BindingDB	211295
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	20.0 nM	None	ChEMBL
IC50	20.0 nM	N/A	BindingDB

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