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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1615950
Molecular formula	C19H22N4O2
IUPAC name	N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-2-phenylbutanamide
Molecular weight	338.411
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM211002 US9247759, 4-37 CHEMBL3971132
Inchi Key	BVMAXAGGAXGNBC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H22N4O2/c1-4-17(15-8-6-5-7-9-15)19(24)21-16-10-20-23(11-16)12-18-13(2)22-25-14(18)3/h5-11,17H,4,12H2,1-3H3,(H,21,24)
PubChem CID	57944932
ChEMBL	CHEMBL3971132
IUPHAR	N/A
BindingDB	211002
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	500.0 nM	N/A	BindingDB
IC50	500.0 nM	None	ChEMBL

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