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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 10
Species	Mus musculus (Mouse)
Gene	Ccr10
Synonym	G-protein coupled receptor 2 Chemokine C-C receptor 9 CCR10 CCR-10 CC-CKR-10 C-C CKR-10 GPR-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	362
Amino acid sequence	MGTKPTEQVSWGLYSGYDEEAYSVGPLPELCYKADVQAFSRAFQPSVSLMVAVLGLAGNGLVLATHLAARRTTRSPTSVHLLQLALADLLLALTLPFAAAGALQGWNLGSTTCRAISGLYSASFHAGFLFLACISADRYVAIARALPAGQRPSTPSRAHLVSVFVWLLSLFLALPALLFSRDGPREGQRRCRLIFPESLTQTVKGASAVAQVVLGFALPLGVMAACYALLGRTLLAARGPERRRALRVVVALVVAFVVLQLPYSLALLLDTADLLAARERSCSSSKRKDLALLVTGGLTLVRCSLNPVLYAFLGLRFRRDLRRLLQGGGCSPKPNPRGRCPRRLRLSSCSAPTETHSLSWDN
UniProt	Q9JL21
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3879821
IUPHAR	67
DrugBank	N/A

Ligand

Name	CHEMBL3889627
Molecular formula	C23H27N5O3S
IUPAC name	N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide
Molecular weight	453.561
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.6
Synonyms	SCHEMBL1034287 BDBM50198921
Inchi Key	BRJXJOWXAFLRTE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27N5O3S/c1-17-8-13-28(14-9-17)23(29)21(10-15-27-12-3-4-18(27)16-24)26-32(30,31)22-6-2-5-20-19(22)7-11-25-20/h2-7,11-12,17,21,25-26H,8-10,13-15H2,1H3
PubChem CID	44252324
ChEMBL	CHEMBL3889627
IUPHAR	N/A
BindingDB	50198921
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	25.12 nM	PMID27692854	ChEMBL
IC50	63.1 nM	PMID27692854	ChEMBL
IC50	15848.9 nM	PMID27692854	ChEMBL

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