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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTA1 receptor
TaR-1
TAR1
trace amine receptor 1
TRAR1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL1990510
Molecular formulaC16H23N3O
IUPAC nameN-(4-pyrrolidin-3-ylphenyl)piperidine-1-carboxamide
Molecular weight273.38
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP1.7
SynonymsCHEMBL3971752
1-Piperidinecarboxamide, N-[4-(3-pyrrolidinyl)phenyl]-
BDBM250118
1312559-20-8
US9452980, 28
Inchi KeyASAQMEBUNMNALF-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H23N3O/c20-16(19-10-2-1-3-11-19)18-15-6-4-13(5-7-15)14-8-9-17-12-14/h4-7,14,17H,1-3,8-12H2,(H,18,20)
PubChem CID67239344
ChEMBLCHEMBL3971752
IUPHARN/A
BindingDB250118
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki433.6 nM, NoneBindingDB,ChEMBL

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