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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279594
Molecular formulaC21H22N6O4
IUPAC nameN-benzyl-2-[1-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-2,5-dioxoimidazolidin-4-yl]acetamide
Molecular weight422.445
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP0.6
SynonymsUS9247759, 10-49
BDBM211301
N-benzyl-2-(1-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-2,5-dioxoimidazolidin-4-yl)acetamide
AQDPRGIKDPFALJ-UHFFFAOYSA-N
CHEMBL3946372
Inchi KeyAQDPRGIKDPFALJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H22N6O4/c1-13-17(14(2)31-25-13)12-26-11-16(10-23-26)27-20(29)18(24-21(27)30)8-19(28)22-9-15-6-4-3-5-7-15/h3-7,10-11,18H,8-9,12H2,1-2H3,(H,22,28)(H,24,30)
PubChem CID57422468
ChEMBLCHEMBL3946372
IUPHARN/A
BindingDB211301
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501300.0 nMNoneChEMBL
IC501300.0 nMN/ABindingDB

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