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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 1
Species	Homo sapiens (Human)
Gene	P2RY1
Synonym	ATP receptor Purinergic receptor P2Y1 purinergic receptor P2Y Purinergic receptor platelet ADP receptor P2Y1 receptor P2Y1 P2Y purinoceptor 1 P2Y ATP receptor 1 ADP receptor {ECO:0000303\|PubMed:9038354} P2 purinoceptor subtype Y1 [ Show all ]
Disease	Thrombosis
Length	373
Amino acid sequence	MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
UniProt	P47900
Protein Data Bank	4xnv, 4xnw
GPCR-HGmod model	P47900
3D structure model	This structure is from PDB ID 4xnv.
BioLiP	BL0311594,BL0311596, BL0311593, BL0311590,BL0311591,BL0311592, BL0311589, BL0311588, BL0311595,BL0311597
Therapeutic Target Database	T67818
ChEMBL	CHEMBL4315
IUPHAR	323
DrugBank	N/A

Ligand

Name	SCHEMBL17077212
Molecular formula	C23H26FN5O2S2
IUPAC name	1-[2-(3,3-diethyl-4-fluoro-7-hydroxy-2H-indol-1-yl)phenyl]-3-(3-ethylsulfanyl-1,2,4-thiadiazol-5-yl)urea
Molecular weight	487.612
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	5.9
Synonyms	US9540323, 33
Inchi Key	ALPUPECCFTWDIZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H26FN5O2S2/c1-4-23(5-2)13-29(19-17(30)12-11-14(24)18(19)23)16-10-8-7-9-15(16)25-20(31)26-21-27-22(28-33-21)32-6-3/h7-12,30H,4-6,13H2,1-3H3,(H2,25,26,27,28,31)
PubChem CID	118365989
ChEMBL	N/A
IUPHAR	N/A
BindingDB	260846
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.6 nM	N/A	BindingDB

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