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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTA1 receptor
TaR-1
TAR1
trace amine receptor 1
TRAR1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL1991690
Molecular formulaC16H16ClN3O
IUPAC name4-chloro-N-(6-pyrrolidin-3-ylpyridin-3-yl)benzamide
Molecular weight301.774
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP2.1
SynonymsBenzamide, 4-chloro-N-[6-(3-pyrrolidinyl)-3-pyridinyl]-
(RS)-4-chloro-N-(6-pyrrolidin-3-yl-pyridin-3-yl)-benzamide
ABRIYQXZDGDZAN-UHFFFAOYSA-N
US9452980, 140
1312561-45-7
[ Show all ]
Inchi KeyABRIYQXZDGDZAN-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H16ClN3O/c17-13-3-1-11(2-4-13)16(21)20-14-5-6-15(19-10-14)12-7-8-18-9-12/h1-6,10,12,18H,7-9H2,(H,20,21)
PubChem CID67239828
ChEMBLCHEMBL3912684
IUPHARN/A
BindingDB250230
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki245.2 nM, NoneBindingDB,ChEMBL

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