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GPCR

NameParathyroid hormone/parathyroid hormone-related peptide receptor
SpeciesRattus norvegicus (Rat)
GenePth1r
SynonymParathyroid hormone 1 receptor
PPR
PTH/PTHr receptor
PTH/PTHrP type I receptor
PTH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length591
Amino acid sequenceMGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
UniProtP25961
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL6038
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3964997
Molecular formulaC29H30F3N5O7S
IUPAC name5-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-2-oxa-5,7-diazaspiro[3.4]octane-6,8-dione
Molecular weight649.642
Hydrogen bond acceptor12
Hydrogen bond donor2
XlogP2.6
SynonymsSCHEMBL17104836
US9428505, Compound 10
BDBM64566
Inchi KeyWMHJWHBMOVKVON-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H30F3N5O7S/c1-17-13-20(37-26(40)34-25(39)28(37)15-43-16-28)14-18(2)22(17)7-12-45(41,42)36-10-8-27(9-11-36)24(38)33-23(35-27)19-3-5-21(6-4-19)44-29(30,31)32/h3-6,13-14H,7-12,15-16H2,1-2H3,(H,33,35,38)(H,34,39,40)
PubChem CID76284228
ChEMBLCHEMBL3964997
IUPHARN/A
BindingDB64566
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5012000.0 nM, NoneBindingDB,ChEMBL

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