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GPCR

NamePutative P2Y purinoceptor 10
SpeciesMus musculus (Mouse)
GeneP2ry10
SynonymP2RY10
P2Y10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
DiseaseN/A for non-human GPCRs
Length328
Amino acid sequenceMGSNSTSSAESNCNATYLPFQYSLYATTYIFIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKYLNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAVIWIVVGTACLPFPILRNAGLANSTDSCFADLGYKQMDAVVLVTMVVIAELAGFVIPVITIACCTWKTTVSLKHPPIAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKESIITSCPTVKSTLYFHPFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVN
UniProtQ8BFU7
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562168
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3815043
Molecular formulaC29H46NO10P
IUPAC name(2S)-2-amino-3-[hydroxy-[[(2R,3R)-3-[3-(2-undecoxyphenyl)propanoyloxy]-3,6-dihydro-2H-pyran-2-yl]methoxy]phosphoryl]oxypropanoic acid
Molecular weight599.658
Hydrogen bond acceptor11
Hydrogen bond donor3
XlogP2.4
SynonymsBDBM50177126
Inchi KeyNVYUCSAJWHDWDM-WYMJOSIYSA-N
Inchi IDInChI=1S/C29H46NO10P/c1-2-3-4-5-6-7-8-9-12-19-36-25-15-11-10-14-23(25)17-18-28(31)40-26-16-13-20-37-27(26)22-39-41(34,35)38-21-24(30)29(32)33/h10-11,13-16,24,26-27H,2-9,12,17-22,30H2,1H3,(H,32,33)(H,34,35)/t24-,26+,27+/m0/s1
PubChem CID127048655
ChEMBLCHEMBL3815043
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<1000.0 nMPMID27077565ChEMBL
EC50>1000.0 nMPMID27077565ChEMBL

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