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GPCR

NameHistamine H3 receptor
SpeciesMus musculus (Mouse)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtP58406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3263
IUPHAR264
DrugBankN/A

Ligand

NameCID 44370617
Molecular formulaC14H21N3O6
IUPAC name(E)-but-2-enedioic acid;3-(1H-imidazol-5-yl)propyl N-propylcarbamate
Molecular weight327.337
Hydrogen bond acceptor7
Hydrogen bond donor4
XlogPNone
SynonymsN/A
Inchi KeyCXGNADHMTVMSMN-WLHGVMLRSA-N
Inchi IDInChI=1S/C10H17N3O2.C4H4O4/c1-2-5-12-10(14)15-6-3-4-9-7-11-8-13-9;5-3(6)1-2-4(7)8/h7-8H,2-6H2,1H3,(H,11,13)(H,12,14);1-2H,(H,5,6)(H,7,8)/b;2-1+
PubChem CID44370617
ChEMBLCHEMBL345808
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
ED502.7 mg.kg-1PMID10052966ChEMBL

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