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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	McN-A-343
Molecular formula	C14H18Cl2N2O2
IUPAC name	4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium;chloride
Molecular weight	317.21
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	None
Synonyms	Tox21_500277 (4-Hydroxy-2-butynyl)-1-trimethyl-ammonium-3-chloro-carbanilate chloride 4-[N-(3-Chlorophenyl)carbamoyloxy]-2--butynyl-trimethyl-ammonium chloride Ammonium, (4-hydroxy-2-butynyl)trimethyl-, chloride, m-chlorocarbanilate CHEMBL74300 HMS3372P11 MLS000859939 2-Butyn-1-aminium, 4-((((3-chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-, chloride 55-45-8 Butyl-1-aminium, 4-((((3-chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-, chloride DTXSID80203532 MCN A-343 NCGC00260962-01 SR-01000075310 4-(N-[3-CHLOROPHENYL]-CARBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE AC1Q1S2A CCG-221581 HMS2235M19 UNII-CW55R761RE (4-Hydroxy-2-butynyl)-1-trimethylammonium-m-chlorocarbanilate chloride 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride API0006795 CW55R761RE LP00277 MolPort-006-822-477 A 343 C 7041 EU-0100277 MCN A-343 chloride SCHEMBL2977744 SR-01000075310-1 (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium chloride AKOS024456563 HMS3260H16 MFCD00055068 4-{[(3-chlorophenyl)carbamoyl]oxy}-n,n,n-trimethylbut-2-yn-1-aminium chloride B6715 D02BOW LS-18194 NCGC00093733-01 4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride AC1L1LFI Carbanilic acid, m-chloro-, ester with (4-hydroxy-2-butynyl)trimethylammonium chloride GTPL290 McN-A 343 SMR000058673 [ Show all ]
Inchi Key	CXFZFEJJLNLOTA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
PubChem CID	5926
ChEMBL	CHEMBL74300
IUPHAR	290
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<63.0 umol.kg-1	PMID7990109	ChEMBL
IC50	34116.0 nM	Bioorg. Med. Chem. Lett., (1992) 2:8:803	ChEMBL
Ki	1000.0 - 19952.6 nM	PMID7680092	IUPHAR

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