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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesMus musculus (Mouse)
GeneTrhr
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseN/A for non-human GPCRs
Length393
Amino acid sequenceMENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
UniProtP21761
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2467
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3781024
Molecular formulaC23H27BrN6O4
IUPAC name(2S)-N-[(2S)-3-(1-benzyl-2-bromoimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight531.411
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP0.7
SynonymsBDBM50158392
Inchi KeyMCTSLSUHNRJPGD-BZSNNMDCSA-N
Inchi IDInChI=1S/C23H27BrN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
PubChem CID127032562
ChEMBLCHEMBL3781024
IUPHARN/A
BindingDB50158392
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<50000.0 nMPMID26854379BindingDB,ChEMBL
IC50<50000.0 nMPMID26854379BindingDB,ChEMBL

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