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GPCR

NameD(4) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD4
SynonymD4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
d(2C) dopamine receptor
DiseaseErectile dysfunction
Psychotic disorders
Schizophrenia
Length467
Amino acid sequenceMGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProtP21917
Protein Data Bank5wiv, 5wiu
GPCR-HGmod modelP21917
3D structure modelThis structure is from PDB ID 5wiv.
BioLiPBL0394824, BL0394826, BL0394825
Therapeutic Target DatabaseT24983
ChEMBLCHEMBL219
IUPHAR217
DrugBankBE0009376, BE0000389

Ligand

NameCHEMBL241641
Molecular formulaC29H29Cl2N3O
IUPAC nameN-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-4-(2-phenylethynyl)benzamide
Molecular weight506.471
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP6.8
SynonymsBDBM50221664
N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(2-phenylethynyl)benzamide
Inchi KeyIZRFSGDNQRHHKW-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H29Cl2N3O/c30-26-9-6-10-27(28(26)31)34-21-19-33(20-22-34)18-5-4-17-32-29(35)25-15-13-24(14-16-25)12-11-23-7-2-1-3-8-23/h1-3,6-10,13-16H,4-5,17-22H2,(H,32,35)
PubChem CID44436606
ChEMBLCHEMBL241641
IUPHARN/A
BindingDB50221664
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity29.0 %PMID17827018ChEMBL
Ki330.0 nMPMID17827018ChEMBL

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