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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	CHEMBL241211
Molecular formula	C27H25Cl2N3O
IUPAC name	N-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]-3-(2-phenylethynyl)benzamide
Molecular weight	478.417
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	6.1
Synonyms	BDBM50221677 N-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)-3-(2-phenylethynyl)benzamide
Inchi Key	IDICUFRCUIOPKM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H25Cl2N3O/c28-24-10-5-11-25(26(24)29)32-18-16-31(17-19-32)15-14-30-27(33)23-9-4-8-22(20-23)13-12-21-6-2-1-3-7-21/h1-11,20H,14-19H2,(H,30,33)
PubChem CID	44436599
ChEMBL	CHEMBL241211
IUPHAR	N/A
BindingDB	50221677
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	8.0 %	PMID17827018	ChEMBL
Ki	12.0 nM	PMID17827018	ChEMBL

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