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GPCR

NameProteinase-activated receptor 2
SpeciesHomo sapiens (Human)
GeneF2RL1
SynonymProtease-activated receptor-2
PAR2
PAR-2
GPR11
G-protein coupled receptor 11
[ Show all ]
DiseaseN/A
Length397
Amino acid sequenceMRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
UniProtP55085
Protein Data Bank5ndz, 5ndd
GPCR-HGmod modelP55085
3D structure modelThis structure is from PDB ID 5ndz.
BioLiPBL0377325, BL0377326
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5963
IUPHAR348
DrugBankN/A

Ligand

NameCHEMBL3752956
Molecular formulaC26H35FN4O4
IUPAC nameN-[(2S)-3-cyclohexyl-1-[[(2S,3S)-1-[(3-fluorophenyl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-1,2-oxazole-5-carboxamide
Molecular weight486.588
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP5.1
SynonymsN/A
Inchi KeyGJBUNTXVUMKFQT-HYVJGQCMSA-N
Inchi IDInChI=1S/C26H35FN4O4/c1-3-17(2)23(26(34)28-16-19-10-7-11-20(27)14-19)31-24(32)21(15-18-8-5-4-6-9-18)30-25(33)22-12-13-29-35-22/h7,10-14,17-18,21,23H,3-6,8-9,15-16H2,1-2H3,(H,28,34)(H,30,33)(H,31,32)/t17-,21-,23-/m0/s1
PubChem CID56639888
ChEMBLCHEMBL3752956
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity28.0 %PMID26725028ChEMBL
Inhibition74.0 %PMID26725028ChEMBL

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