You can:
Name | D(4) dopamine receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | DRD4 |
Synonym | D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor |
Disease | Erectile dysfunction Psychotic disorders Schizophrenia |
Length | 467 |
Amino acid sequence | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC |
UniProt | P21917 |
Protein Data Bank | 5wiv, 5wiu |
GPCR-HGmod model | P21917 |
3D structure model | This structure is from PDB ID 5wiv. |
BioLiP | BL0394824, BL0394826, BL0394825 |
Therapeutic Target Database | T24983 |
ChEMBL | CHEMBL219 |
IUPHAR | 217 |
DrugBank | BE0009376, BE0000389 |
Name | CHEMBL256492 |
---|---|
Molecular formula | C21H27FN2O3 |
IUPAC name | 1-[[4-(2-fluoroethoxy)-3-methoxyphenyl]methyl]-4-(2-methoxyphenyl)piperazine |
Molecular weight | 374.456 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 3.6 |
Synonyms | BDBM50373708 |
Inchi Key | FKHJOYFNYFVDRF-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H27FN2O3/c1-25-19-6-4-3-5-18(19)24-12-10-23(11-13-24)16-17-7-8-20(27-14-9-22)21(15-17)26-2/h3-8,15H,9-14,16H2,1-2H3 |
PubChem CID | 44454735 |
ChEMBL | CHEMBL256492 |
IUPHAR | N/A |
BindingDB | 50373708 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.8 nM | PMID18164618 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417