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GPCR

NameMuscarinic acetylcholine receptor M3
SpeciesMus musculus (Mouse)
GeneChrm3
Synonymcholinergic receptor, muscarinic 3
cholinergic receptor, muscarinic 3, cardiac
Chrm-3
cholinergic receptor
M3 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length589
Amino acid sequenceMTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProtQ9ERZ3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5105
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1183133
Molecular formulaC8H12N4OS
IUPAC name3-(methylsulfanylmethyl)-5-(1,4,5,6-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazole
Molecular weight212.271
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP-0.3
SynonymsBDBM50057399
5-(3-Methylsulfanylmethyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine; TFA
Inchi KeyCWNXCRZJZQAFDR-UHFFFAOYSA-N
Inchi IDInChI=1S/C8H12N4OS/c1-14-4-7-11-8(13-12-7)6-2-9-5-10-3-6/h5-6H,2-4H2,1H3,(H,9,10)
PubChem CID10727260
ChEMBLN/A
IUPHARN/A
BindingDB50057399
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC505800.0 nMPMID9111297BindingDB

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