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GPCR

NameD(4) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD4
SynonymD4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
d(2C) dopamine receptor
DiseaseErectile dysfunction
Psychotic disorders
Schizophrenia
Length467
Amino acid sequenceMGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProtP21917
Protein Data Bank5wiv, 5wiu
GPCR-HGmod modelP21917
3D structure modelThis structure is from PDB ID 5wiv.
BioLiPBL0394824, BL0394826, BL0394825
Therapeutic Target DatabaseT24983
ChEMBLCHEMBL219
IUPHAR217
DrugBankBE0009376, BE0000389

Ligand

NameCHEMBL1086790
Molecular formulaC19H18N2
IUPAC name11,19-diazapentacyclo[12.6.1.02,11.03,8.018,21]henicosa-1(20),3,5,7,14(21),15,17-heptaene
Molecular weight274.367
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP3.6
SynonymsBDBM50313914
2,6,7,9,10,14b-Hexahydroindolo[3'',4'':3,4,5]azepino[2,1-a]-isoquinoline
Inchi KeyBOVIKQWJNPOZRM-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H18N2/c1-2-6-15-13(4-1)8-10-21-11-9-14-5-3-7-17-18(14)16(12-20-17)19(15)21/h1-7,12,19-20H,8-11H2
PubChem CID45379377
ChEMBLCHEMBL1086790
IUPHARN/A
BindingDB50313914
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID20180564ChEMBL

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