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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	N,N-Di-n-propylserotonin
Molecular formula	C16H24N2O
IUPAC name	3-[2-(dipropylamino)ethyl]-1H-indol-5-ol
Molecular weight	260.381
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.0
Synonyms	CHEMBL141706 PDSP2_000013 3-[2-(dipropylamino)ethyl]-1h-indol-5-ol N,N-Di-n-propyl-2-((5-hydroxyindol-3-yl)amino)ethane ZINC5832849 BDBM50020702 PDSP1_000013 3-(2-Dipropylamino-ethyl)-1H-indol-5-ol CTK4H6243 PDSP2_000753 36288-75-2 AC1L54DG 1H-Indol-5-ol, 3-(2-(dipropylamino)ethyl)- PDSP1_000765 3-(2-Dipropylamino-ethyl)-1H-indol-5-ol(DiPS) DTXSID80189827 SCHEMBL8891077 5-Hydroxy-N,N-dipropyltryptamine AC1Q7A16 N,N-dipropylserotonin 1H-Indol-5-ol,3-[2-(dipropylamino)ethyl]- [ Show all ]
Inchi Key	CWMOGUBWVJQDSL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H24N2O/c1-3-8-18(9-4-2)10-7-13-12-17-16-6-5-14(19)11-15(13)16/h5-6,11-12,17,19H,3-4,7-10H2,1-2H3
PubChem CID	169764
ChEMBL	CHEMBL141706
IUPHAR	N/A
BindingDB	50020702
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.1 nM	PMID2965244	BindingDB,ChEMBL

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