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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1615819
Molecular formulaC17H18N4O3
IUPAC nameN-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-4-methoxybenzamide
Molecular weight326.356
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP1.9
SynonymsUS9247759, 4-17
CHEMBL3899757
BDBM210983
Inchi KeyIILSWFQBVNCJBK-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H18N4O3/c1-11-16(12(2)24-20-11)10-21-9-14(8-18-21)19-17(22)13-4-6-15(23-3)7-5-13/h4-9H,10H2,1-3H3,(H,19,22)
PubChem CID57945012
ChEMBLCHEMBL3899757
IUPHARN/A
BindingDB210983
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50260.0 nMN/ABindingDB
IC50260.0 nMNoneChEMBL

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