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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278962
Molecular formula	C15H15N3O3S2
IUPAC name	3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2-oxo-N-(thiophen-2-ylmethyl)-1,3-thiazole-5-carboxamide
Molecular weight	349.423
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.9
Synonyms	US9247759, 4-116 CHEMBL3923914 BDBM211076
Inchi Key	HTNBMTMXDVDYNY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H15N3O3S2/c1-9-12(10(2)21-17-9)7-18-8-13(23-15(18)20)14(19)16-6-11-4-3-5-22-11/h3-5,8H,6-7H2,1-2H3,(H,16,19)
PubChem CID	57422325
ChEMBL	CHEMBL3923914
IUPHAR	N/A
BindingDB	211076
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2279.0 nM	N/A	BindingDB
IC50	2279.0 nM	None	ChEMBL

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