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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameAC1MVSHT
Molecular formulaC18H21N5O3S
IUPAC name1-(2,5-dimethoxyphenyl)-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]thiourea
Molecular weight387.458
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.2
Synonyms1-(2,5-dimethoxyphenyl)-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]thiourea
US9247759, 4-113
CHEMBL3975082
BDBM211073
SCHEMBL1278654
[ Show all ]
Inchi KeyHSXFVFAIMWPDTK-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H21N5O3S/c1-11-15(12(2)26-22-11)10-23-9-13(8-19-23)20-18(27)21-16-7-14(24-3)5-6-17(16)25-4/h5-9H,10H2,1-4H3,(H2,20,21,27)
PubChem CID3688271
ChEMBLCHEMBL3975082
IUPHARN/A
BindingDB211073
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC505240.0 nMNoneChEMBL
IC505240.0 nMN/ABindingDB

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