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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1615626
Molecular formulaC23H27N5O5
IUPAC name3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1-[[3-(2-hydroxyethoxy)phenyl]methyl]-5,5-dimethylimidazolidine-2,4-dione
Molecular weight453.499
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP1.4
SynonymsUS9247759, 12-63
CHEMBL3948947
BDBM211412
Inchi KeyHOQKILFZGNLRBR-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27N5O5/c1-15-20(16(2)33-25-15)14-26-13-18(11-24-26)28-21(30)23(3,4)27(22(28)31)12-17-6-5-7-19(10-17)32-9-8-29/h5-7,10-11,13,29H,8-9,12,14H2,1-4H3
PubChem CID53374284
ChEMBLCHEMBL3948947
IUPHARN/A
BindingDB211412
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50280.0 nMN/ABindingDB
IC50280.0 nMNoneChEMBL

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