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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1615384
Molecular formula	C15H15FN4O3S
IUPAC name	N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-2-fluorobenzenesulfonamide
Molecular weight	350.368
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	1.7
Synonyms	US9247759, 4-100 CHEMBL3983515 BDBM211060
Inchi Key	HAPUNHPFCABVDD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H15FN4O3S/c1-10-13(11(2)23-18-10)9-20-8-12(7-17-20)19-24(21,22)15-6-4-3-5-14(15)16/h3-8,19H,9H2,1-2H3
PubChem CID	57945004
ChEMBL	CHEMBL3983515
IUPHAR	N/A
BindingDB	211060
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8510.0 nM	N/A	BindingDB
IC50	8510.0 nM	None	ChEMBL

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