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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279293
Molecular formula	C22H26N6O3
IUPAC name	1-benzyl-2-butyl-4-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1,2,4-triazolidine-3,5-dione
Molecular weight	422.489
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.0
Synonyms	US9247759, 10-95 CHEMBL3962515 BDBM211347
Inchi Key	DCIGZSLAFMGHSL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N6O3/c1-4-5-11-26-21(29)28(22(30)27(26)13-18-9-7-6-8-10-18)19-12-23-25(14-19)15-20-16(2)24-31-17(20)3/h6-10,12,14H,4-5,11,13,15H2,1-3H3
PubChem CID	57944920
ChEMBL	CHEMBL3962515
IUPHAR	N/A
BindingDB	211347
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	410.0 nM	N/A	BindingDB
IC50	410.0 nM	None	ChEMBL

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