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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279276
Molecular formula	C19H18FN5O3
IUPAC name	3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1-[(3-fluorophenyl)methyl]imidazolidine-2,4-dione
Molecular weight	383.383
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	1.6
Synonyms	CRSPWRLXFSRFTN-UHFFFAOYSA-N 3-(1((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-fluorobenzyl)imidazolidine-2,4-dione 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-fluorobenzyl)imidazolidine-2,4-dione CHEMBL3900806 US9247759, 10-27 BDBM211279 [ Show all ]
Inchi Key	CRSPWRLXFSRFTN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H18FN5O3/c1-12-17(13(2)28-22-12)10-24-9-16(7-21-24)25-18(26)11-23(19(25)27)8-14-4-3-5-15(20)6-14/h3-7,9H,8,10-11H2,1-2H3
PubChem CID	57422449
ChEMBL	CHEMBL3900806
IUPHAR	N/A
BindingDB	211279
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	60.0 nM	None	ChEMBL
IC50	60.0 nM	N/A	BindingDB

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