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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278991
Molecular formula	C15H15N5O2
IUPAC name	N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]pyridine-3-carboxamide
Molecular weight	297.318
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	0.8
Synonyms	US9247759, 4-46 CHEMBL3916540 BDBM211011
Inchi Key	BSGWKHQBKRIJCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H15N5O2/c1-10-14(11(2)22-19-10)9-20-8-13(7-17-20)18-15(21)12-4-3-5-16-6-12/h3-8H,9H2,1-2H3,(H,18,21)
PubChem CID	57945009
ChEMBL	CHEMBL3916540
IUPHAR	N/A
BindingDB	211011
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1050.0 nM	N/A	BindingDB
IC50	1050.0 nM	None	ChEMBL

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