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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1616720
Molecular formulaC24H27N5O6
IUPAC namemethyl 2-[3-[[3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl]phenoxy]acetate
Molecular weight481.509
Hydrogen bond acceptor8
Hydrogen bond donor0
XlogP2.0
SynonymsUS9247759, 12-75
CHEMBL3956008
BDBM211424
Inchi KeyBPCCQJWTSTYFRM-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H27N5O6/c1-15-20(16(2)35-26-15)13-27-12-18(10-25-27)29-22(31)24(3,4)28(23(29)32)11-17-7-6-8-19(9-17)34-14-21(30)33-5/h6-10,12H,11,13-14H2,1-5H3
PubChem CID53374572
ChEMBLCHEMBL3956008
IUPHARN/A
BindingDB211424
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50530.0 nMNoneChEMBL
IC50530.0 nMN/ABindingDB

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