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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278840
Molecular formula	C17H19N5OS
IUPAC name	1-benzyl-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]thiourea
Molecular weight	341.433
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.2
Synonyms	US9247759, 4-110 CHEMBL3951005 BDBM211070
Inchi Key	BOWCRJVUXZTNGA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19N5OS/c1-12-16(13(2)23-21-12)11-22-10-15(9-19-22)20-17(24)18-8-14-6-4-3-5-7-14/h3-7,9-10H,8,11H2,1-2H3,(H2,18,20,24)
PubChem CID	57422322
ChEMBL	CHEMBL3951005
IUPHAR	N/A
BindingDB	211070
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1097.0 nM	None	ChEMBL
IC50	1097.0 nM	N/A	BindingDB

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