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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279313
Molecular formula	C20H21N5O4
IUPAC name	3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1-[[3-(hydroxymethyl)phenyl]methyl]imidazolidine-2,4-dione
Molecular weight	395.419
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	0.6
Synonyms	US9247759, 10-33 BCGUGNZDXFGGAW-UHFFFAOYSA-N CHEMBL3950626 BDBM211285 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-(hydroxymethyl)benzyl)imidazolidine-2,4-dione
Inchi Key	BCGUGNZDXFGGAW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21N5O4/c1-13-18(14(2)29-22-13)10-24-9-17(7-21-24)25-19(27)11-23(20(25)28)8-15-4-3-5-16(6-15)12-26/h3-7,9,26H,8,10-12H2,1-2H3
PubChem CID	57422454
ChEMBL	CHEMBL3950626
IUPHAR	N/A
BindingDB	211285
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	300.0 nM	None	ChEMBL
IC50	300.0 nM	N/A	BindingDB

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