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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278560
Molecular formula	C17H15N5O3
IUPAC name	N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1,3-benzoxazole-5-carboxamide
Molecular weight	337.339
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.8
Synonyms	US9247759, 4-72 CHEMBL3971823 BDBM211037
Inchi Key	AXBKOAZUUQDADD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H15N5O3/c1-10-14(11(2)25-21-10)8-22-7-13(6-19-22)20-17(23)12-3-4-16-15(5-12)18-9-24-16/h3-7,9H,8H2,1-2H3,(H,20,23)
PubChem CID	57422301
ChEMBL	CHEMBL3971823
IUPHAR	N/A
BindingDB	211037
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2600.0 nM	None	ChEMBL
IC50	2600.0 nM	N/A	BindingDB

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