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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278959
Molecular formula	C17H19N5O2S
IUPAC name	1-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-3-(2-methoxyphenyl)thiourea
Molecular weight	357.432
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.2
Synonyms	US9247759, 4-106 CHEMBL3909170 BDBM211066
Inchi Key	AFZVNBNXHHHQGB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19N5O2S/c1-11-14(12(2)24-21-11)10-22-9-13(8-18-22)19-17(25)20-15-6-4-5-7-16(15)23-3/h4-9H,10H2,1-3H3,(H2,19,20,25)
PubChem CID	57422318
ChEMBL	CHEMBL3909170
IUPHAR	N/A
BindingDB	211066
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2607.0 nM	None	ChEMBL
IC50	2607.0 nM	N/A	BindingDB

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