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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	CHEMBL3910551
Molecular formula	C22H15F3N2O3
IUPAC name	2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetic acid
Molecular weight	412.368
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	4.6
Synonyms	US9249085, I(x) BDBM204964 2-[3-[[3-Cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluoro-phenoxy]acetic acid BMYPINGCOBKLIH-UHFFFAOYSA-N SCHEMBL14783775
Inchi Key	BMYPINGCOBKLIH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H15F3N2O3/c23-17-3-1-2-15(9-17)16-7-13(10-26)6-14(8-16)11-27-22-18(24)4-5-19(21(22)25)30-12-20(28)29/h1-9,27H,11-12H2,(H,28,29)
PubChem CID	89443595
ChEMBL	CHEMBL3910551
IUPHAR	N/A
BindingDB	204964
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	27.0 nM	, None	BindingDB,ChEMBL

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