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Name | Prostaglandin E2 receptor EP2 subtype |
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Species | Homo sapiens (Human) |
Gene | PTGER2 |
Synonym | PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 [ Show all ] |
Disease | Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder [ Show all ] |
Length | 358 |
Amino acid sequence | MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL |
UniProt | P43116 |
Protein Data Bank | N/A |
GPCR-HGmod model | P43116 |
3D structure model | This predicted structure model is from GPCR-EXP P43116. |
BioLiP | N/A |
Therapeutic Target Database | T38529 |
ChEMBL | CHEMBL1881 |
IUPHAR | 341 |
DrugBank | BE0000368 |
Name | CHEMBL3971730 |
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Molecular formula | C21H15F4NO4 |
IUPAC name | 2-[2,4-difluoro-3-[[2-fluoro-3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid |
Molecular weight | 421.348 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 3 |
XlogP | 4.6 |
Synonyms | US9249085, I(f) ALLKGBRYGHMWCV-UHFFFAOYSA-N 2-[2,4-Difluoro-3-[[2-fluoro-3-(3-fluorophenyl)-5-hydroxy-phenyl]methylamino]phenoxy]acetic acid BDBM204946 SCHEMBL14774800 |
Inchi Key | ALLKGBRYGHMWCV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H15F4NO4/c22-13-3-1-2-11(6-13)15-8-14(27)7-12(19(15)24)9-26-21-16(23)4-5-17(20(21)25)30-10-18(28)29/h1-8,26-27H,9-10H2,(H,28,29) |
PubChem CID | 71516448 |
ChEMBL | CHEMBL3971730 |
IUPHAR | N/A |
BindingDB | 204946 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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EC50 | 160.0 nM | , None | BindingDB,ChEMBL |
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